RNF5 inhibitor inh-02

RNF5 inhibitor inh-02 是 E3 泛素连接酶 RNF5/RMA1 的有效抑制剂。RNF5 inhibitor inh-02 导致 F508del 突变纯合子支气管上皮细胞 F508del-CFT 显著挽救 (EC50=2.2 uM)。RNF5 inhibitor inh-02 可用于囊性纤维化研究。

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库存: 现货

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数量
5mg

￥1950.00

1560.00

- +
10mg

￥3387.00

2710.00

- +
25mg

￥7137.00

5710.00

- +
50mg

￥12050.00

9640.00

- +

已选 0 种 0 瓶

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货号: ajcx35158
CAS: 324579-65-9
别名:
分子式: C23H20N4S
分子量: 384.5
纯度: >98%
溶解度: DMSO : 83.33 mg/mL (216.72 mM; ultrasonic and warming and heat to 60°C)
储存: Store at 2-8°C,protect from light
库存: 现货

Background

RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 leads to significant F508del-CFTR rescue (EC50=2.2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh-02 can be used for cystic fibrosis research[1].

[1]. Elvira Sondo, et al. Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell Chem Biol. 2018 Jul 19;25(7):891-905.e8.