PFM39 是一种 Mirin 类似物，是一种有效的选择性 MRE11 核酸外切酶抑制剂。PFM39 阻断 dsDNA 磷酸骨架的旋转，但不抑制 TmMre11 或人类 MRE11/MRN 核酸内切酶活性。
PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibits TmMre11 or human MRE11/MRN endonuclease activity[1].
PFM39 (100 μM) treatment impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR)[1]. PFM39 (50 μM) inhibits homologous recombination (HR) without significantly increasing NHEJ[1].
[1]. Atsushi Shibata , et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18.
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