AS-0141

AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM)，具有抗肿瘤活性，详情请参考文献 WO2019165473A1，compound I-D。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶，在细胞周期中对 DNA 复制的启动至关重要。

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库存: 现货

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价格

促销价

数量
5mg

￥5400.00

4320.00

- +
10mg

￥9175.00

7340.00

- +
25mg

￥17625.00

14100.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx35560
CAS: 1402057-88-8
别名: Cdc7-IN-6
分子式: C21H22F3N5O4
分子量: 465.43
纯度: >98%
溶解度: DMSO : 83.33 mg/mL (179.04 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

AS-0141 (Cdc7-IN-6) is a potent Cdc7 kinase inhibitor (IC50=4 nM), extracted from patent WO2019165473A1, compound I- D, has anti-tumor activity[1][2].

AS-0141 (Cdc7-IN-6) demonstrates potent inhibitory activity (IC50<3 µμ) in a range of solid tumor cell lines, including those of bladder (5673, RT1 12/84), sarcoma (143B, CADO-ES1, RD-ES, A673), colon and cecum (Colo-205, DLD-l, LS1034, SK-CO-l, SNU-C1), renal (U0.31), head-and-neck (CNE-2Z, RPMI-2650), melanoma (A2058, A875), and gastric (HGC-27) lineages[1].

[1]. Christian Andrew HASSIG, et al. Methods of treatment of cancer comprising cdc7 inhibitors. WO2019165473A1.