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  • QS-21
QS-21的可视化放大

QS-21

QS-21 是一种免疫刺激型皂甙,可作为有效的疫苗佐剂。QS-21 通过作用于抗原呈递细胞 (APC) 和 T 细胞,刺激 Th2 体液和 Th1 细胞介导的免疫反应。QS-21 可以激活 NLRP3 炎性小体,释放 caspase-1 依赖性细胞因子 IL-1β 和 IL-18。

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¥5287-8412
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4230-6730
QS-21的二维码

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  • 货号: ajcx35564
  • CAS: 141256-04-4
  • 别名: 皂苷QA21V1,Stimulon
  • 分子式: C92H148O46
  • 分子量: 1990.13
  • 纯度: >98%
  • 溶解度:
  • 储存: Store at -20°C
  • 库存: 现货

Background

QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3].


Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively[3].


[1]. Fernández-Tejada A, et al. Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis. Acc Chem Res. 2016;49(9):1741-1756.
[2]. Marty-Roix R, et al. Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants. J Biol Chem. 2016;291(3):1123-1136
[3]. Lacaille-Dubois MA. Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: A review. Phytomedicine. 2019;60:152905.

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