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- WKYMVM-NH2 TFA
WKYMVM-NH2 TFA
WKYMVM-NH2 TFA 是有效的 N-甲酰肽受体 FPR1 和 FPRL1/2 的激动剂，同时可以激活一些白细胞效应功能，如趋化性、激活补体受体-3 及 NADPH 氧化酶。
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包装价格促销价数量
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1mg￥1212.00970.00- +
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5mg￥2612.002090.00- +
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10mg￥4100.003280.00- +
- 货号: ajcx35578
- CAS: 1435781-74-0
- 别名:
- 分子式: C43H62F3N9O9S2
- 分子量: 970.13
- 纯度: ＞98%
- 溶解度: Water : 12.5 mg/mL (12.88 mM; Need ultrasonic)
- 储存: -20°C, away from moisture
- 库存: 现货
Background
WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2][3].
WKYMVM-NH2 TFA (10-1000 nM; 24 hours) induces Caco-2 cells proliferation[3].
WKYMVM-NH2 TFA (8 mg/kg; six times; for 5 days) ameliorates DSS-induced ulcerative colitis[3].WKYMVM-NH2 TFA affects cytokine (IL-17, IFN-γ, IL-6, IL-1β and TNF-α) profiles in the DSS colitis model[3].
[1]. Christophe T, et al. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J Biol Chem. 2001 Jun 15;276(24):21585-93.
[2]. Christophe T, et al. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. Scand J Immunol. 2002 Nov;56(5):470-6.
[3]. Sang Doo Kim, et al. The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis. Exp Mol Med. 2013 Sep; 45(9): e40.
