Bambuterol-D9 ((±)-Bambuterol-D9) hydrochloride 是 Bambuterol 的氘代物。Bambuterol ((±)-Bambuterol) 是长效 β-肾上腺素受体激动剂 (LABA)，是terbutaline的原药。
Bambuterol-D9 ((±)-Bambuterol-D9) hydrochloride is the deuterium labeled Bambuterol. Bambuterol ((±)-Bambuterol) hydrochloride is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Bambuterol, From Wikipedia
动态评分
0.0