现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • HeE1-2Tyr
HeE1-2Tyr的可视化放大

HeE1-2Tyr

HeE1-2Tyr 是一种 pyridobenzothiazole,是一种黄病毒 RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂。HeE1-2Tyr 在体外显着抑制西尼罗河、登革热和 SARS-CoV-2 RdRps (IC50 为 27.6 &#181M) 的活性。

原价
¥2725-14425
价格
2180-11540
HeE1-2Tyr的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx35804
  • CAS: 2245195-67-7
  • 别名:
  • 分子式: C33H30N2O6S
  • 分子量: 582.67
  • 纯度: >98%
  • 溶解度: DMSO : 100 mg/mL (171.62 mM; Need ultrasonic)
  • 储存: Store at -20°C
  • 库存: 现货

Background

HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro[1][2].


HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC50 of 2.1 µM, as well as all the four Dengue virus (DENV) serotypes, with IC50 ranging from 6.8 to 15 µM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 µM[1].Additionally, upon infection of human HEK 293 cells (CC50 of 50 µM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC50 values ranging from 3.9 to 12 µM[1]. HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV)[2].


[1]. Delia Tarantino, et al. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res. 2016 Oct;134:226-235.
[2]. Milan Dejmek, et al. Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication. Viruses. 2021 Aug 11;13(8):1585.

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服