PD-1-IN-24

PD-1-IN-24 (compound 1) 是具有口服活性的 PD-1 的抑制剂。

原价

￥4850-8637

价格

￥ 3880-6910

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库存: 现货

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产品引用

货号: ajcx35838
CAS: 2360909-50-6
别名:
分子式: C27H26F3NO3
分子量: 469.5
纯度: >98%
溶解度: DMSO : 100 mg/mL (212.99 mM; ultrasonic and warming and heat to 60°C)
储存: Store at -20°C, sealed storage, away from moisture and light
库存: 现货

Background

PD-1-IN-24 (compound 1) is an orally active PD-1 inhibitor[1].

PD-1-IN-24 (compound 1, 15mg/kg, PO, BID) exhibits TGI(%) of 19.96% in the subcutaneous 4T1 murine breast cancer model in BALB/c mice[1].PD-1-IN-24 (compound 1, 15mg/kg, PO, BID) dose-dependently inhibits tumor growth in the Bl6F10 models with TGI% of 35.59% (30 mg/kg), 38.87% (60 mg/kg) and 47.35% (120 mg/kg), respectively[1].

[1]. Wang, Yuguang, et al. Combination of small molecule inhibitor of the PD-1/PD-L1 interaction and anti-PD-1 antibody for treatment of cancer. Patent WO 2021052386.

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PD-1-IN-24

PD-1-IN-24详情

Background