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An inhibitor of cardiac myosin ATPase
Aficamten is an inhibitor of cardiac myosin ATPase (IC50 = 1.26 ?M for the bovine enzyme).1 It reduces fractional shortening in isolated rat cardiac ventricular myocytes (IC50 = 7.9 ?M) and in rats in a dose-dependent manner.
1.Chuang, C., Collibee, S., Ashcraft, L., et al.Discovery of aficamten (CK-274), a next-generation cardiac myosin inhibitor for the treatment of hypertrophic cardiomyopathyJ. Med. Chem.64(19)14142-14152(2021)
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