PROTAC CBP/P300 Degrader-1

PROTAC CBP/P300 Degrader-1 是一种有效的 PROTAC CBP/P300 降解剂。PROTAC CBP/P300 Degrader-1 有效抑制多个癌细胞系的细胞活力。

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库存: 现货

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数量
5mg

￥11337.00

9070.00

- +
10mg

￥17625.00

14100.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx35890
CAS: 2484739-48-0
别名:
分子式: C46H53F2N11O6
分子量: 893.98
纯度: >98%
溶解度: DMSO : 173.33 mg/mL (193.89 mM; Need ultrasonic)
储存: Store at -20°C, sealed storage, away from moisture and light
库存: 现货

Background

PROTAC CBP/P300 Degrader-1 is a potent PROTAC CBP/P300 degrader. PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancer cell lines[1].

PROTAC CBP/P300 Degrader-1 shows LNCaP prostate cancer cell viability inhibition (IC50=0.4 nM). PROTAC CBP/P300 Degrader-1 (10 nM) induces degradation of P300 (≥ 80%)[1].PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancel cell lines (IC50s ranging from 0.1-141.4 nM for HEL, NOMO-1, MOLM-13, HL-60, MEG-01, MM.IS, MM.1R, NCL-H929, RPM-8226, AMO-1, WSU-DLCL2, Karpas-422, Pfeiffer, SU-DHL-1, LNCap clone FGC, VCap; 22RV1, NCI-H520, NCI-H703, LK-2, MCE-7, and SK-BR-3 cells)[1].

[1]. Jing Liu, et al. Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use. WO2020173440A1.