Valopicitabine dihydrochloride

Valopicitabine (NM283) dihydrochloride 是一种核苷类似物，是强效抗 HCV 剂的 2’-C-甲基胞苷 (NM107) 的口服生物利用前药。NM107 竞争性抑制 NS5B 聚合酶，导致链终止。

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库存: 现货

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数量
5mg

￥4637.00

3710.00

- +
10mg

￥7337.00

5870.00

- +
25mg

￥13887.00

11110.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx36064
CAS: 640725-71-9
别名: NM283 dihydrochloride
分子式: C15H26Cl2N4O6
分子量: 429.3
纯度: >98%
溶解度:
储存: Store at -20°C, protect from light, stored under nitrogen
库存: 现货

Background

Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable prodrug of the potent anti-HCV agent 2’-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination[1][2].

Valopicitabine (NM283) (100 mg/kg; oral administration; Sprague-Dawley Rats) dihydrochloride shows the Cmax, AUC, t1/2, and tmax were 3.624 μg/mL, 8.95 μg h/mL, 0.64 hours and 1 hour, respectively[2].

[1]. Liu-Young G, et al. Hepatitis C protease and polymerase inhibitors in development. AIDS Patient Care STDS. 2008;22(6):449-457.
[2]. Pierra C, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2’-C-methylcytidine. J Med Chem. 2006;49(22):6614-6620.