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  • T0467
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T0467

T0467 以 PINK1 依赖的方式激活线粒体 parkin 易位。T0467 不诱导多巴胺能神经元中 PINK1 的线粒体聚集。T0467 是一种潜在的PINK1-Parkin 信号激活化合物,可用于帕金森病及相关疾病的研究。

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¥3600-5612
价格
2880-4490
T0467的二维码

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  • 货号: ajcx36128
  • CAS: 859518-94-8
  • 别名:
  • 分子式: C24H26F3N5
  • 分子量: 441.49
  • 纯度: >98%
  • 溶解度: DMSO : 33.33 mg/mL (75.49 mM; Need ultrasonic)
  • 储存: Store at -20°C
  • 库存: 现货

Background

T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson’s disease and related disorders research[1].


T0467 (2.5-20 μM; 3 hours) stimulates the mitochondrial translocation of GFP-Parkinover 12 μM in HeLa/GFP-Parkin cells[1]. When HeLa/GFP-Parkin cells are treated with 20 μM T0467 for 3 h, GTP-Parkin is translocated to the mitochondria in approximately 21% of cells[1].T0467 does not show obvious toxicity in Drosophila at concentrations Drosophila larval muscles[1].


[1]. Kahori Shiba-Fukushima, et al. A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling. iScience. 2020 May 22;23(5):101048.

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