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- mTOR (mammalian target of Rapamycin)
- HIF-2α-IN-4
HIF-2α-IN-4
HIF-2α-IN-4 是一种有效的 HIF-2α 翻译抑制剂，IC50 值为 5 μM。HIF-2α-IN-4 降低组成型和缺氧诱导的 HIF-2α 蛋白表达。HIF-2α-IN-4 将 5’UTR 铁响应元件与氧传感联系起来。
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包装价格促销价数量
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5mg￥762.00610.00- +
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10mg￥1300.001040.00- +
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25mg￥2725.002180.00- +
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50mg￥4850.003880.00- +
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100mg￥8100.006480.00- +
- 货号: ajcx36146
- CAS: 882268-69-1
- 别名:
- 分子式: C9H9N3O4S2
- 分子量: 287.32
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5’UTR iron-responsive element to oxygen sensing[1].
HIF-2α-IN-4 (compound 76) (10 μM; 786-O cells) decreases HIF-2α mRNA translation in an mTOR-independent manner[1].HIF-2α-IN-4 decreases HIF-2α protein and HIF-2α target gene expression in normoxia and hypoxia[1].
[1]. Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5’UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848.
