Cinacalcet-D3
An internal standard for the quantification of cinacalcet
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包装价格促销价数量
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1mg￥3050.002440.00- +
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5mg￥11337.009070.00- +
- 货号: ajcx36280
- CAS: N/A
- 别名: AMG 073-D3
- 分子式: C22H19D3F3N
- 分子量: 360.43
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
Cinacalcet-d3 is intended for use as an internal standard for the quantification of cinacalcet by GC- or LC-MS. Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor (CaSR; EC50 = 79.4 nM in HEK293T cells expressing the human receptor).1 In vivo, cinacalcet (0.1-10 mg/kg, s.c.) decreases plasma levels of parathyroid hormone (PTH) in rats. It also decreases plasma levels of PTH and parathyroid cell proliferation in a mouse model of primary hyperparathyroidism.2 Formulations containing cinacalcet have been used in the treatment of secondary hyperparathyroidism due to end-stage renal disease and hypercalcemia in patients with parathyroid carcinoma.
1.Ma, J.N., Owens, M., Gustafsson, M., et al.Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptorJ. Pharmacol. Exp. Ther.337(1)275-284(2011) 2.Imanishi, Y., Kawata, T., Kenko, T., et al.Cinacalcet HCl suppresses Cyclin D1 oncogene-derived parathyroid cell proliferation in a murine model for primary hyperparathyroidismCalcif. Tissue Int.89(1)29-35(2011)
