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- PKD (Protein kinase D)
- BAY-8400
BAY-8400
BAY-8400是一种口服活性、有效和选择性 DNA 依赖蛋白激酶 (DNA-PK) 抑制剂(IC50=81 nM)。BAY-8400 可用于癌症研究。
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包装价格促销价数量
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1mg￥1737.001390.00- +
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- 货号: ajcx36316
- CAS: 2763602-59-9
- 别名:
- 分子式: C21H17F2N5O
- 分子量: 393.39
- 纯度: ＞98%
- 溶解度: DMSO : 62.5 mg/mL (158.88 mM; ultrasonic and warming and heat to 60°C)
- 储存: Store at -20°C
- 库存: 现货
Background
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM). BAY-8400 can be used for the research of cancer[1].
BAY-8400 (150 mg/kg; p.o.) increases the antitumor efficacy. BAY-8400 shows useful aqueoussolubility and oral bioavailability across species[1].
[1]. Berger M, et al. BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies [published online ahead of print, 2021 Aug 24]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00762.
