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- CCF0058981
CCF0058981
CCF0058981 (CCF981) 是一种 3-氯苯基类似物，一种非共价SARS-CoV-2 3CLpro (SC2) 抑制剂，IC50 为 68 nM。CCF0058981 抑制SC1 (SARS-CoV-1 3CLpro)，IC50 为 19 nM。CCF0058981 具有抗病毒功效，具有用于 COVID-19 研究的潜力。
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包装价格促销价数量
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5mg￥2725.002180.00- +
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10mg￥4312.003450.00- +
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25mg￥9175.007340.00- +
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50mg￥14425.0011540.00- +
- 货号: ajcx36348
- CAS: N/A
- 别名: CCF981
- 分子式: C24H19ClN6O
- 分子量: 442.9
- 纯度: ＞98%
- 溶解度: DMSO : 25 mg/mL (56.45 mM; ultrasonic and adjust pH to 2 with HCl)
- 储存: Store at -20°C
- 库存: 现货
Background
CCF0058981 (CCF981), 3-chlorophenyl analogue, is a noncovalent SARS-CoV-2 3CLpro (SC2) inhibitor with an IC50 of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CLpro) with an IC50 of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COVID-19 research[1].
CCF0058981 (CCF981) has cytopathic effect (CPE) inhibition (EC50=497 nM) and plaque reduction (EC50=558 nM) in vitro viral replication[1]. CCF0058981 has the 50% cytotoxic concentration (CC50) in the CPE antiviral assay of >50 μM[1]. CCF0058981 has a T1/2 of 21.1 min, a CLlnt of 141 mL/min?kg in Human liver microsomes[1].
[1]. Sang Hoon Han, et al. Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL pro). J Med Chem. 2021 Aug 4;acs.jmedchem.1c00598.
