YAP/TAZ inhibitor-2
YAP/TAZ inhibitor-2 是一种有效的具有口服活性的 TEAD-YAP/TAZ 抑制剂，EC50 值为 3 nM。YAP/TAZ inhibitor-2 显示出抗增殖活性。YAP/TAZ inhibitor-2 显示出抗肿瘤活性。
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包装价格促销价数量
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5mg￥2725.002180.00- +
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10mg￥4100.003280.00- +
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25mg￥8100.006480.00- +
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50mg￥12825.0010260.00- +
- 货号: ajcx38976
- CAS: 2762617-31-0
- 别名:
- 分子式: C19H14F4N4O
- 分子量: 390.33
- 纯度: ＞98%
- 溶解度: DMSO : 100 mg/mL (256.19 mM; Need ultrasonic)
- 储存: Store at -20°C
- 库存: 现货
Background
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity[1].
YAP/TAZ inhibitor-2 (compound 5) (0-20000 nM; 24 h) shows antiproliferative activity with an IC50 value of 5.33 nM in NCI-H226 cells[1].
YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) shows anti-tumor activity with no significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model)[1].
[1]. Xu, xiaofeng, et al. Bicyclic compounds, compositions and use thereof. WO2022037568A1.
