BI8626
BI8626 是一种泛素连接酶 HUWE1 特异性拮抗剂，IC50 为 0.9 μM。
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包装价格促销价数量
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5mg￥2725.002180.00- +
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10mg￥4100.003280.00- +
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25mg￥7550.006040.00- +
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50mg￥13350.0010680.00- +
- 货号: ajcx39010
- CAS: 1875036-75-1
- 别名:
- 分子式: C25H28N8
- 分子量: 440.54
- 纯度: ＞98%
- 溶解度: DMSO : 83.33 mg/mL (189.15 mM; Need ultrasonic)
- 储存: Store at -20°C
- 库存: 现货
Background
BI8626 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 0.9 μM[1].
BI8626 induces HUWE1 ectopically expresses to abolishe ubiquitination of MCL1 in HeLa cells[1].BI8626 suppresses colony formation of Ls174T cells with estimated IC50 value of 0.7 μM, and BI8622 (1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1[1].BI8626 (0-50 μM; 0-6 hours) retards the degradation of MCL1 in response to UV irradiation to the same extent as depletion of HUWE1 in U2OS cells[1].
[1]. Peter S, et al. Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.EMBO Mol Med. 2014 Dec;6(12):1525-41.
