γ-Linolenic Acid methyl ester
A dietary ω-6 PUFA
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包装价格促销价数量
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50mg￥312.00250.00- +
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100mg￥550.00440.00- +
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250mg￥1337.001070.00- +
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1g￥3600.002880.00- +
- 货号: ajci4282
- CAS: 16326-32-2
- 别名: r-亚麻酸甲酯,Methyl GLA,Methyl γ-Linolenate
- 分子式: C19H32O2
- 分子量: 292.5
- 纯度: ＞98%
- 溶解度: ≤100mg/ml in DMSO;100mg/ml in dimethyl formamide
- 储存: Store at -20°C
- 库存: 现货
Background
γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist.
LTB 4, a potent neutrophil chemoattractant, is present at high concentrations in psoriatic lesions, bronchoalveolar lavage in asthmatics and rectal dialysates in patients with inflammatory bowel disease.
In vitro: γ-Linolenic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA was identified as an ω-6 fatty acid which could be elongated to arachidonic acid for endogenous eicosanoid synthesis. GLA was found to be a weak leukotriene B4 (LTB4) receptor antagonist, which was able to inhibit [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 μM [1].
In vivo: In an in-vivo model of LTB4-induced bronchoconstriction, ricinelaidic acid andγ-Linolenic acid methyl ester at a 1 mg/kg i.v. dose could result in 46% and 53% inhibition, respectively, indicating that essential fatty acids are LTB4 receptor antagonists, which may account in part for their reported anti-inflammatory activities [1].
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Yagaloff, K.?A.,Franco, L.,Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukotrienes and Essential Fatty Acids 52, 293-297 (1995).
