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  • Calpeptin
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Calpeptin

A calpain inhibitor

原价
¥612-14962
价格
490-11970
Calpeptin的二维码

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  • 货号: ajci4926
  • CAS: 117591-20-5
  • 别名:
  • 分子式: C20H30N2O4
  • 分子量: 362.47
  • 纯度: >98%
  • 溶解度: ≥ 87.6 mg/mL in DMSO, ≥ 96.6 mg/mL in EtOH
  • 储存: Desiccate at 4°C
  • 库存: 现货

Background

IC50: 5 nM for human calpain 1


Calpeptin is a calpain inhibitor.


As a calcium-dependent intracellular cysteine protease, calpain plays an key role in various cellular processes including cell differentiation, growth and apoptosis. In rheumatoid arthritis patients, over-expression of calpains are observed in arthritic synovial fluid and are thought to play critical roles in various cellular processes.


In vitro: Calpeptin reduced production of TGF-b1, IL-6, angiopoietin-1 and collagen synthesis from lung fibroblasts. Calpeptin also reduced both angiopoietin-1-dependent migration and IL-6-dependent proliferation of the cells, which could be the underlying mechanism of the preventive effect of Calpeptin on pulmonary fibrosis [1].


In vivo: The preventive effect of calpeptin has been examined on bleomycin-induced pulmonary fibrosis in mice. Histological examinations and quantitative measurements of related proteins in bleomycin-treated mouse lung tissues with or without calpeptin were performed. Calpeptin histologically ameliorated bleomycininduced pulmonary fibrosis in mice. Results showed that calpeptin decreased the expression of IL-6, TGF-b1, angiopoietin-1 and collagen type Ia1 mRNA in mouse lung tissues [1].


Clinical trial: N/A

Reference:
[1] Tabata C,Tabata R,Nakano T.? The calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice. Clin Exp Immunol.2010 Dec;162(3):560-7.

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