Actagardin

A tetracyclic lantibiotic

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1mg

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货号: ajci5346
CAS: 59165-34-3
别名: 阿肽加定,Antibiotic A 3802-IV-3,Gardimycin
分子式: C81H124N20O24S4
分子量: 1890.2
纯度: >98%
溶解度: Soluble in ethanol;methanol;DMSO;dimethyl formamide
储存: Store at -20°C
库存: 现货

Background

Actagardin is a tetracyclic antibiotic.

Actagardin is a tetracyclic antibiotic produced by several species of Actinoplanes.

In vitro: During the repeated fermentations of actagardin, two new compounds, named D and E, were isolated. Compound D was found to be twice as active as actagardin against Streptococcus pyogenes C 203 and four times more active than actagardin against Staphylococcus aureus ATCC 6538, S. pneumoniae UC 41, and S. aureus TOUR in the in-vitro tests [1].

In vivo: Animal study showed that compound D was also more effective than the parent compound actagardin against experimental infections in mice with either S. pyogenes C 203 or S. aureus TOUR, after sc administration. However, compound D was ineffective at doses up to 150 mg/kg when given orally to mice infected with S. pyogenes C 203. Moreover, compound D (LD50 1,250 mg/kg, mice, ip) was about 2.5 times more toxic than actagardine (3,310 mg/kg). In addition, compound E showed practically no in vitro activity up to 50 μg/ml against the tested organisms [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Malabarba A, Landi M, Pallanza R, Cavalleri B.? Physico-chemical and biological properties of actagardine and some acid hydrolysis products. J Antibiot (Tokyo). 1985 Nov;38(11):1506-11.