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- 5-HT Receptor
- SB269970 HCl
SB269970 HCl
A 5-HT7A and adrenergic α2 receptor antagonist
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包装价格促销价数量
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10mg￥1462.001170.00- +
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50mg￥4800.003840.00- +
- 货号: ajci5780
- CAS: 261901-57-9
- 别名: SB-269970A
- 分子式: C18H29ClN2O3S
- 分子量: 388.95
- 纯度: ＞98%
- 溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 1 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
SB269970 HCl is a potent and selective antagonist of 5-HT7 receptor with pKi value of 8.3 [1].
SB269970 is a selective antagonist of 5-HT7 receptor. It shows at least 100-fold selective against 5-HT7 over a variety of receptors and enzymes. SB269970 prevents 5-CT from binding to h5-HT7(a) in H293 cells and human cloned 5-HT7 receptor in guinea-pig cerebral cortex membranes with pKi values of 8.9 and 8.3, respectively. SB269970 also inhibits adenylyl cyclase activity stimulated by 5-CT both in 5-HT7(a)/ HEK293 (pA2 of 8.5) membranes and in guinea-pig hippocampus (pKB of 8.3). In vehicle-treated animals, SB269970 almost completely inhibits the 5-CT-induced hypothermia with ED50 value of 2.96mg/kg [1].
参考文献:
[1] Hagan J J, Price G W, Jeffrey P, et al. Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist. British journal of pharmacology, 2000, 130(3): 539-548.
