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  • IRAK inhibitor 3
IRAK inhibitor 3的可视化放大

IRAK inhibitor 3

IRAK inhibitor 3 是一种从专利 WO2008030579 A2 中提取的白细胞介素-1 (IL-I) 受体相关激酶 (IRAK) 激酶调节剂。

原价
¥2112-6925
价格
1690-5540
IRAK inhibitor 3的二维码

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  • 库存: 现货
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  • 货号: ajci6448
  • CAS: 1012343-93-9
  • 别名: 4-[[[3-(3,4-二甲氧基苯基)咪唑并[1,2-B]哒嗪-6-基]氨基]甲基]苯磺酰胺
  • 分子式: C21H21N5O4S
  • 分子量: 439.49
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.


IRAK inhibitor 3 is an IRAK modulator, which can be used for treating an inflammatory condition, cell proliferative disorder, immune disorder[1].


参考文献:
[1]. Thomas Durand-Reville, et al. Irak modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder. WO 2008030579 A2.

Protocol

Kinase experiment:

5 μL of a solution of IRAK inhibitor 3 at a concentration of 50 μM or less in 1% (v/v) DMSO is added to the wells of a 96-well area Black Polystyrene plates. The final concentrations in the reaction well are 10 μM ATP, 0.5 μM IRAK4 CH373, 1.6 μM IRAKI peptide, 1 mM MgCl2, 2 mM DTT, 5 mM MnCl2, 0.01 % BSA, and 0.01 % Tween-20. The volume of the reaction is 45 μL. The reaction mixture is incubated at room temperature for 30 minutes and stopped with the addition of 5 μL of 100 mM EDTA[1].

参考文献:

[1]. Thomas Durand-Reville, et al. Irak modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder. WO 2008030579 A2.

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