An antimicrotubule agent
Epothilone A (Epo A) is a naturally occurring microtubule-stabilizing macrolide that was first isolated from the myxobacterium?Sorangium cellulosum. The IC50 value of Epothilone A in HCT-116 cell line is?4.4 nM [1].
It has been found that the SKOV-3 human ovarian cancer cells were susceptible to Epothilone A with IC50 value of 20.4?±?1.4 nM [2]. The antiproliferative capacity of Epothilone A in SKOV-3 cell line (measured as IC50?after 72?h continuous treatment) was six times greater than that of PTX’s. Besides, Epothilone A induced time coursedependent apoptosis and necrosis [2].?
参考文献:
[1] Regueiro-Ren A1,?Borzilleri RM,?Zheng X,?Kim SH,?Johnson JA,?Fairchild CR,?Lee FY,?Long BH,?Vite GD. Synthesis?and?biological?activity?of?novel?epothilone?aziridines. Org Lett.?2001 Aug 23;3(17):2693-6.
[2] Rogalska A1,?Marczak A,?Gajek A,?Szwed M,??liwińska A,?Drzewoski J,?Jó?wiak Z. Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B. Toxicol In Vitro.?2013 Feb;27(1):239-49.
动态评分
0.0