Lomefloxacin HCl

A broad-spectrum fluoroquinolone antibiotic

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库存: 现货

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50mg

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货号: ajci7556
CAS: 98079-52-8
别名: 盐酸洛美沙星; SC47111A hydrochloride
分子式: C17H19F2N3O3.HCl
分子量: 387.81
纯度: >98%
溶解度: ≥ 6.3mg/mL in Water with gentle warming; 1mg/mL in DMSO (Need ultrasonic)
储存: 4°C, protect from light
库存: 现货

Background

Lomefloxacin hydrochloride is a fluoroquinolone antibiotic.Target: AntibacterialLomefloxacin hydrochloride is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited [1].

参考文献:
[1]. http://www.drugbank.ca/drugs/DB00978