Ibotenic acid

An excitotoxic NMDA and metabotropic glutamate receptor agonist

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5mg

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货号: ajci7672
CAS: 2552-55-8
别名: 鹅膏氨酸,(RS)-Ibotenic acid; DL-Ibotenic acid
分子式: C5H6N2O4
分子量: 158.11
纯度: >98%
溶解度: Water: 10mM
储存: Desiccate at -20°C
库存: 现货

Background

Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.

Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only activation of NMDA receptors is involved in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC50=77.3±8 μM (n=5) as measured by release of lactate dehydrogenase to the culture media[1].

参考文献:
[1]. Zinkand WC, et al. Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptormechanisms. Mol Chem Neuropathol. 1992 Feb-Apr;16(1-2):1-10.