莫西沙星是一种具有口服活性的 8-甲氧基喹诺酮类抗菌药物，用于治疗急性细菌性鼻窦炎、慢性支气管炎的急性细菌性加重和社区获得性肺炎。
Moxifloxacin is an orally bio-available, broad spectrum bacterial gyrase-inhibiting fluoroquinolone antibiotic [1].
Moxifloxacin at 50 μg/mL has been reported to induce a significant reduction of viable cells. A remarkable anti-proliferative activity of moxifloxacin has been proved in the concentrations between 50 and 1500?μg/mL. Moreover, moxifloxacin could lead to signs of cellular damage which were seen like binucleation in a dose-dependent manner [2].
Rats intravenously injected with moxifloxacin at 100 mg/kg have shown the increase of Serum glucose and serum epinephrine?concentrations as well as the release of histamine. However, moxifloxacin at 75 mg/kg did not show any effects on serum epinephrine, glucose or histamine concentrations increase [3].
参考文献:
[1] Iatropoulos MJ1,?Jeffrey AM,?Enzmann HG,?von Keutz E,?Schlueter G,?Williams GM. Assessment of chronic toxicity and carcinogenicity in an accelerated cancer bioassay in rats of moxifloxacin, a quinolone antibiotic. Exp Toxicol Pathol.?2001 Oct;53(5):345-57.
[2] Sobolewska B1,?Hofmann J,?Spitzer MS,?Bartz-Schmidt KU,?Szurman P,?Yoeruek E. Antiproliferative and cytotoxic properties of moxifloxacin on rat retinal ganglion cells. Curr Eye Res.?2013 Jun;38(6):662-9.
[3] Ishiwata Y1,?Takahashi Y,?Nagata M,?Yasuhara M. Effects of moxifloxacin on serum glucose concentrations in rats. Biol Pharm Bull.?2013;36(4):686-90.
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