N-Benzylacetamidine (hydrobromide)

Potent, selective inhibitor of iNOS

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库存: 现货

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5mg

￥1100.00

880.00

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10mg

￥2037.00

1630.00

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50mg

￥8550.00

6840.00

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100mg

￥14812.00

11850.00

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货号: ajci9596
CAS: 186545-76-6
别名:
分子式: C9H12N2 · HBr
分子量: 229.1
纯度: >98%
溶解度: ≤25mg/ml in ethanol;15mg/ml in DMSO;20mg/ml in dimethyl formamide
储存: Store at -20°C
库存: 现货

Background

IC50: 0.20 μM: inhibits inducible nitric oxide synthases (iNOS).

IC50: 350 μM: blocks endothelial nitric oxide synthases (eNOS).

N-Benzylacetamidine is a potent and selective inhibitor of iNOS compared to eNOS. NOS is essential to the formation of nitric oxide (NO) via the NADPH- and O2-dependent oxidation of L-arginine, which plays a role in regulating many pathological and physiological processes, including smooth muscle relaxation and neurotransmission. INOS contributes to immune response and inflammation while eNOS plays a vital role in regulating vascular tone.

In vitro: N-Benzylacetamidine showed good iNOS and almost negligible eNOS inhibition in THP-1 cells, a human myelomonocytic leukemia cell line [1].

In vivo: Up to now, in vivo study of N-Benzylacetamidine is still in the development stage.

Reference:
[1].? Maccallini, C., Patruno, A., Besker, N., Ali, J., Ammazzalorso, A., & De Filippis, B. et al. Synthesis, Biological Evaluation, and Docking Studies of N-Substituted Acetamidines as Selective Inhibitors of Inducible Nitric Oxide Synthase. Journal of Medicinal Chemistry. 2009; 52(5): 1481-1485.