现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Pirlimycin
Pirlimycin的可视化放大

Pirlimycin

An antibiotic of the lincosamide class

原价
¥3225-12575
价格
2580-10060
Pirlimycin的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajci9914
  • CAS: 79548-73-5
  • 别名: 吡利霉素,U-57930E
  • 分子式: C17H31ClN2O5S
  • 分子量: 411
  • 纯度: >98%
  • 溶解度: Soluble in ethanol; methanol; DMSO; dimethyl formamide; water
  • 储存: Store at -20°C
  • 库存: 现货

Background

Pirlimycin, a lincosamide antibiotic, is effective against gram-positive bacteria, including Staphylococcus, Bacteroides, Streptococcus, and Plasmodium. It functions via inhibiting protein synthesis in bacteria by inducing premature dissociation of the peptidyl-tRNA from the ribosome.


In vitro: Pirlimycin showed activity against Helicobacter pylori with a minimal inhibitory concentration [MIC] 50 of 4 μg/ml and an MIC90 of 64 μg/ml [1].


In vivo: Cows were treated with 50 mg of pirlimycin via two intramammary infusions per quarter at a 24- hour interval (2-day) for 2, 5, or 8 days. Pirlimycin showed antibiotic therapy against environmental Streptococcus spp and Staphylococcus aureus intramammary individual and combined infections [1]. Specifically, pirlimycin cured environmental Streptococcus spp infections in 66.7% (14/21), 85% (17/20), 100% (14/14) in the 2-day group, 5-day group and 8-day group, respectively. S. aureus infections were cured by the treatment of pirlimycin in 13.3% (2/15), 31.3% (5/16), 83.3% (5/6) in the 2-day group, 5-day group and 8-day group, respectively. Furthermore, S. aureus, S. dysgalactiae subsp dysgalactiae, and Enterococcus spp intramammary infections were eliminated by the extended treatment of pirlimycin in 8-day group [2].

参考文献:
[1].? Westblom, T., Midkiff, B., & Czinn, S. In vitro susceptibility ofHelicobacter pylori to trospectomycin, pirlimycin (U-57930E), mirincamycin (U-24729A) and N-demethyl clindamycin (U-26767A). European Journal of Clinical Microbiology & Infectious Diseases. 1993; 12(7): 560-562.
[2].? B. E. Gillespie, H. Moorehead, P. Lunn, H. H. Dowlen, D. L. Johnson, K. C. Lamar, M. J. Lewis, S. J. Ivey, J. W. Hallberg, S. T. Chester, and S. P. Oliver. Efficacy of extended pirlimycin hydrochloride therapy for treatment of environmental Streptococcus spp and Staphylococcus aureus intramammary infections in lactating dairy cows. Veterinary Therapeutics. 2002; 3(4): 373-80.

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服