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  • 10-DEBC hydrochloride
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10-DEBC hydrochloride

A selective inhibitor of Akt

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10-DEBC hydrochloride的二维码
  • 库存: 现货
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  • 包装
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    促销价
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  • 1mg
    ¥737.00
    590.00
    - +
  • 5mg
    ¥2000.00
    1600.00
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  • 10mg
    ¥2562.00
    2050.00
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  • 50mg
    ¥10075.00
    8060.00
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  • 货号: ajci10254
  • CAS: 925681-41-0
  • 别名: 2-氯-N,N-二乙基-10H-吩恶嗪-10-丁胺盐酸盐,Akt Inhibitor X
  • 分子式: C20H25N2OCl.HCl
  • 分子量: 381.34
  • 纯度: >98%
  • 溶解度: 16mg/mL in ethanol, 12.5mg/mL in DMSO, 5mg/mL in DMF
  • 储存: Store at -20°C
  • 库存: 现货

Background

Akt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt with an IC50 value of 1-2 μM.[1] This compound has been shown to block IGF-1-stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells with IC50 values of 2-5 μM.[1] Inhibition of Akt phosphorylation by 5 μM of this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.[1]


Reference:
[1]. Thimmaiah, K.N., Easton, J.B., Germain, G.S., et al. Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. The Journal of Biological Chemisty 280(36), 31924-31935 (2005).

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