Ac-YVAD-AFC
A caspase-1 and -4 substrate
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1mg￥387.00310.00- +
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5mg￥1237.00990.00- +
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10mg￥2287.001830.00- +
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- 货号: ajci10894
- CAS: 219137-85-6
- 别名: Caspase-1 Substrate VI (Fluorogenic), Ac-Tyr-Val-Ala-Asp-7-amino-4-Trifluoromethlcoumarin
- 分子式: C33H36F3N5O10
- 分子量: 719.66
- 纯度: ＞98%
- 溶解度: 10mg/ml in DMSO; 1mg/ml in DMF
- 储存: Store at -20°C, protect from light
- 库存: 现货
Background
Ac-YVAD-AFC is a substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4.[1],[2] Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.
Reference：
[1]. Talanian, R.V., Quinlan, C., Trautz, S., et al. Substrate specificities of caspase family proteases. J. Biol. Chem. 272(15), 9677-9682 (1997).
[2]. Marcelli, M., Cunningham, G.R., Haidacher, S.J., et al. Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP. Cancer Res. 58(1), 76-83 (1998).
