An α1-AR antagonist
Doxazosin Mesylate is a selective, long-lasting antagonist?of?α1-adrenergic receptor [1].
Doxazosin Mesylate has been reported to potentiate?contraction response to 5-HT in a dose-dependent manner [1]. Doxazosin significantly reduced alcohol drinking and increased water intake in adult male P rats [2].
Studies has indicated that doxazosin could inhibit TNF-α?expression in LPS-induced systemic?inflammation?model as well as reduce the MCP-1 production in LPS-induced pulmonary inflammation?model. Additionally, Doxazosin decreased thickness of footpad in the delayed-type hypersensitivity mice model. Doxazosin had been reported to slightly reduce MCP-1 level in the peritoneal cavity of mice induced by thioglycollate [3].
参考文献:
[1] Zhao Y1,?Cao XB,?Ren LM. Doxazosin selectively potentiates contraction to serotonin via 5-HT?A receptors in longitudinal muscle strips of the rabbit gastric body. Can J Physiol Pharmacol.?2014 Mar;92(3):197-204.
[2] O'Neil ML1,?Beckwith LE,?Kincaid CL,?Rasmussen DD. The α1-adrenergic receptor antagonist, doxazosin, reduces alcohol drinking in alcohol-preferring (P) Rats. Alcohol Clin Exp Res.?2013 Feb;37(2):202-12.
[3] Tung D1,?Ciallella J,?Cheung PH,?Saha S. Novel anti-inflammatory effects of doxazosin in rodent models of inflammation. Pharmacology.?2013;91(1-2):29-34.
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