A non-selective monovalent cation ionophore
Dinactin is a macrotetrolide antibiotic that acts as an ionophore for monovalent cations, such as K+, NH4+, and Rb+.1 It is commonly used to study membrane properties.[1],[2] Dinactin is a component of a macrotetralide-rich antifungal mixture produced by Streptomyces.[3] Dinactin inhibits T-cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.[4]
Reference:
[1]. Laprade, R., Grenier, F., Pagé-Dansereau, M., et al. Carrier-mediated ion transport in lipid bilayer membranes. Can. J. Biochem. Cell Biol. 62(8), 738-751 (1984).
[2]. Lapointe, J.-Y., and Laprade, R. Kinetics of carrier-mediated ion transport in two new types of solvent-free lipid bilayers. Biophys. J. 39(2), 141-150 (1982).
[3]. Silva, L.J., Crevelin , E.J., Souza, W.R., et al. Streptomyces araujoniae Produces a Multiantibiotic Complex with Ionophoric Properties to Control Botrytis cinerea. Phytopathology 104(12), 1298-1305 (2014).
[4]. Umland, S.P., Shah, H., Jakway, J.P., et al. Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation. Am. J. Respir. Cell Mol. Biol. 20(3), 481-492 (1999).
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