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- WAY 213613
WAY 213613
WAY 213613 是一种有效的选择性人 EAAT2 抑制剂。
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包装价格促销价数量
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10mg￥3675.002940.00- +
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50mg￥15337.0012270.00- +
- 货号: ajci11560
- CAS: 868359-05-1
- 别名: N-[4-(2-溴-4,5-二氟苯氧基)苯基]-L-天冬酰胺
- 分子式: C16H13BrF2N2O4
- 分子量: 415.19
- 纯度: ＞98%
- 溶解度: <41.51mg/ml in DMSO; <41.51mg/ml in 1eq. NaOH
- 储存: Desiccate at RT
- 库存: 现货
Background
WAY-213613 is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC50 of 85 nM EAAT2. It displays 59- and 44-fold selectivity over EAAT1 and EAAT3 (IC50s are 5 and 3.8 μM, respectively). WAY-213613 shows no activity at ionotropic and metabotropic glutamate receptors. It is a potential tool for the elucidation of EAAT2 function[1][2].
参考文献:
[1]. Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13.
[2]. Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9(8):e102136.
