6-fluoro-DL-Tryptophan

A serotonin synthesis inhibitor

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
50mg

￥562.00

450.00

- +
100mg

￥900.00

720.00

- +
250mg

￥1925.00

1540.00

- +
500mg

￥2937.00

2350.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci12242
CAS: 7730-20-3
别名: 6-氟-DL-色氨酸,DL-6-Fluorotryptophan,NSC 9364
分子式: C11H11FN2O2
分子量: 222.2
纯度: >98%
溶解度: ≤0.1mg/ml in methanol;1mg/ml in acetic acid (2%)
储存: Store at -20°C
库存: 现货

Background

6-fluoro-DL-Tryptophan is a serotonin (5-HT) synthesis inhibitor.

Serotonin or 5-hydroxytryptamine (5-HT), a monoamine neurotransmitter, is biochemically derived from tryptophan. Serotonin is primarily present in the gastrointestinal tract, blood platelets, and the central nervous system of animals. Serotonin is considered to be a contributor to feelings of well-being and happiness.

In vitro: The potential competition was investigated between L-tryptophan (TRP) and 6-fluoro-DL-tryptophan (6-F-TRP). In equilibrium dialysis experiments, albumin bound about 80% of TRP and 50% of 6-F-TRP. Competitive inhibition was assessed as the decrease in the apparent Ka of TRP in the presence of 6-F-TRP, with no modification of the N value [1].

In vivo: Rats werer administered 6-fluoro-DL-tryptophan (6F-Trp) and its neurochemical effects on central catechole and indole were evaluated. Results showed that neither norepinephrine nor dopamine and its major metabolites were affected by 6F-Trp. With regard to serotonin (5-HT), 6F-Trp could induce a transient depletion in all the studied brain areas, with a maximum of about 60-65% obtained between 1 and 3 hr. After 6 hr, 5-HT levels returned to control values. In addition, the 5-hydroxyindolacetic acid (5-HIAA) level was also reduced 3 hr after 6F-Trp administration. A large dose-dependent increase in tryptophan was seen in the four brain areas, mainly due to an inhibition of tryptophan incorporation into protein, as demonstrated by experiments with mouse neuroblastoma cells [2].

Clinical trial: So far, no clinical study has been conducted.

参考文献:
[1] Chanut, E.?,Zini, R.,Trouvin, J.H., et al. Albumin binding and brain uptake of 6-fluoro-DL-tryptophan: Competition with L-tryptophan. Biochemical Pharmacology 44(10), 2082-2085 (1992).
[2] Chanut, E.?,Trouvin, J.H.,Bondoux, D., et al. Metabolism of 6-fluoro-DL-tryptophan and its specific effects on the rat brain serotoninergic pathway. Biochemical Pharmacology 45(5), 1049-1057 (1992).