FGIN-1-27

A TSPO agonist

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥525.00

420.00

- +
10mg

￥987.00

790.00

- +
25mg

￥1562.00

1250.00

- +
50mg

￥2837.00

2270.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci12276
CAS: 142720-24-9
别名: N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺
分子式: C28H37FN2O
分子量: 436.61
纯度: >98%
溶解度: 30mg/mL in ethanol, 20mg/mL in DMSO
储存: Store at -20°C
库存: 现货

Background

FGIN-1-27 is an indoleacetamide that acts as a high affinity agonist of the 18 kDa translocator protein (TSPO; previously called the peripheral benzodiazepine receptor) with a Ki value of 5 nM.1 It can enhance steroidogenesis of neuroactive steroids such as allopregnanolone.[1] Through this action, FGIN-1-27 indirectly potentiates GABAA receptor signaling to produce anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models.[1]

Reference:
[1]. James, M.L., Selleri, S., and Kassiou, M. Development of ligands for the peripheral benzodiazepine receptor. Current Medicinal Chemistry 13(17), 1991-2001 (2006).