FGIN-1-27

A TSPO agonist

原价

￥525-2837

价格

￥ 420-2270

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库存: 现货

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产品引用

货号: ajci12276
CAS: 142720-24-9
别名: N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺
分子式: C28H37FN2O
分子量: 436.61
纯度: >98%
溶解度: 30mg/mL in ethanol, 20mg/mL in DMSO
储存: Store at -20°C
库存: 现货

Background

FGIN-1-27 is an indoleacetamide that acts as a high affinity agonist of the 18 kDa translocator protein (TSPO; previously called the peripheral benzodiazepine receptor) with a Ki value of 5 nM.1 It can enhance steroidogenesis of neuroactive steroids such as allopregnanolone.[1] Through this action, FGIN-1-27 indirectly potentiates GABAA receptor signaling to produce anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models.[1]

Reference:
[1]. James, M.L., Selleri, S., and Kassiou, M. Development of ligands for the peripheral benzodiazepine receptor. Current Medicinal Chemistry 13(17), 1991-2001 (2006).

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信号通路

生命科学

有机化学

无机化学

材料科学

FGIN-1-27

FGIN-1-27详情

Background