N-Nonyldeoxynojirimycin(NN-DNJ; Nonyl-DNJ)
N-Nonyldeoxynojirimycin(NN-DNJ; Nonyl-DNJ)是一种有效的alpha-glucosidase 和alpha-1,6-glucosidase 抑制剂，IC50 值分别为 0.42 和 8.4 μM，可抑制糖原的降解。
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包装价格促销价数量
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10mg￥750.00600.00- +
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25mg￥1500.001200.00- +
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50mg￥2250.001800.00- +
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100mg￥3750.003000.00- +
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200mg￥6000.000.00- +
- 货号: ajci12552
- CAS: 81117-35-3
- 别名: NN-DNJ; Nonyl-DNJ;N-(n-Nonyl)deoxynojirimycin
- 分子式: C15H31NO4
- 分子量: 289.41
- 纯度: ＞98%
- 溶解度: DMSO : 50 mg/mL (172.77 mM; Need ultrasonic)
- 储存: Store at -20°C
- 库存: 现货
Background
N-Nonyldeoxynojirimycin (NN-DNJ) is a potent inhibitor of alpha-glucosidase and alpha-1,6-glucosidase (IC50s, 0.42, 8.4 μM, respectively), inhibits glycogen breakdown.1
N-Nonyldeoxynojirimycin (NN-DNJ) is an inhibitor of acid α-glucosidase and α-1,6-glucosidase (IC50s = 0.42 and 8.4 μM, respectively).1 NN-DNJ (250 mg/kg per day) increases hepatic glycogen levels in fasted mice and gastrocnemius muscle glycogen levels in both fasted and fed mice. It is a chemical chaperone of β-glucosidase that increases activity by 1.65-fold in patient-derived fibroblasts homozygous for the N370S Gaucher disease mutation when added to the culture medium at a concentration of 5 μM, but inhibits β-glucosidase activity at concentrations greater than 60 μM.2 NN-DNJ inhibits viral replication in BHK-21 cells infected with Japanese encephalitis virus (JEV) or dengue virus serotype 2 (DEN-2) and has protective effects in a mouse model of lethal JEV challenge when administered at a dose of 200 mg/kg per day.3
参考文献:
1. Andersson, U., Reinkensmeier, G., Butters, T.D., et al. Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem. Pharmacol. 67(4), 697-705 (2004).
2. Sawkar, A.R., Cheng, W.-C., Beutler, E., et al. Chemical chaperones increase the cellular activity of N370S β-glucosidase: A therapeutic strategy for Gaucher disease. Proc. Natl. Acad. Sci. USA 99(24), 15428-15433 (2002).
3. Wu, S.-F., Lee, C.-J., Liao, C.-L., et al. Antiviral effects of an iminosugar derivative on flavivirus infections. J. Virol. 76(8), 3596-3604 (2002).
