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Cobimetinib R-对映异构体是 Cobimetinib 活性较低的 R-对映异构体。 Cobimetinib 是一种有效的选择性 MEK 抑制剂。
Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor.
参考文献:
[1]. Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9.
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