A β-lactam antibiotic
Moxalactam (sodium salt) is a β-lactam antibiotic.
β-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most β-lactam antibiotics act by inhibiting cell wall biosynthesis.
Moxalactam is an oxacephem antibiotic and inhibits most commonly occurring gram positive, gram negative, and anaerobic bacteria. Moxalactam was more active against Klebsiella and E coli than cefoperazone. Moxalactam did not inhibit methicillin-resistant S. aureus and Enterococci. Moxalactam had been extremely active against Haemophilis and Neisseria gonorrhoeae. Moxalactam was extremely resistant to hydrolysis by all plasmid and chromosmal β-lactamases [1]. In certain situations, Moxalactam impaired normal hemostasis and prolonged bleeding time [2].
参考文献:
[1].? Neu HC. The in vitro activity, human pharmacology, and clinical effectiveness of new beta-lactam antibiotics. Annu Rev Pharmacol Toxicol. 1982;22:599-642.
[2].? Sattler FR, Weitekamp MR, Ballard JO. Potential for bleeding with the new beta-lactam antibiotics. Ann Intern Med. 1986 Dec;105(6):924-31.
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