L-701,324

An NMDA receptor antagonist

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库存: 现货

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10mg

￥1237.00

990.00

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50mg

￥3600.00

2880.00

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货号: ajci13862
CAS: 142326-59-8
别名: 7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉
分子式: C21H14ClNO3
分子量: 363.8
纯度: >98%
溶解度: DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml,DMSO: 15 mg/ml
储存: Store at RT
库存: 现货

Background

L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.Target: NMDA ReceptorL-701324 is a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents. L-701324 exhibits a beneficial action in the animal model of parkinsonian rigidity, but not that of parkinsonian akinesia. L-701324 (2.5-40 mg/kg, i.p.) dose-dependently decreased the muscle tone enhanced by haloperidol (1-5 mg/kg, i.p.).

参考文献:
[1]. Piotr Wlaz, et al. Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice. Pharmacological Reports 2011,63,1231-1234