BGC 20-761

BGC 20-761 是一种选择性 5-HT6 和多巴胺受体拮抗剂（人受体 Ki 值：5-HT6 (20 nM)、5-HT2A (69 nM)、D2 (140 nM)）。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
10mg

￥3187.00

2550.00

- +
50mg

￥13162.00

10530.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci14426
CAS: 17375-63-2
别名:
分子式: C19H22N2O
分子量: 294.39
纯度: >98%
溶解度: <14.72mg/ml in ethanol; <29.44mg/ml in DMSO
储存: Store at -20°C
库存: 现货

Background

BGC20-761 is a selective and high affinity antagonist of 5-HTC.

The 5-HT6 receptor, a G protein-coupled receptor (GPCR), is a subtype of 5-HT receptor which binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). This protein is expressed almost exclusively in the brain and mediates excitatory neurotransmission.

In cellular level, BGC20-761 (5-methoxy-2-phenyl-N,N-dimethyltryptamine) was shown to selectively blocked 5-HTC.

BGC20-761 was used to study the difference in drug- induced effects in memory consolidation in young and mature rats and human. In young mice, BGC20-761 treatment at doses of 5 mg/kg and 10 mg/kg i.p, dose-dependently reversed a deficit of social recognition induced by scopolamine, an anticholinergic drug that impairs memory at dosage of 0.4 mg/kg i.p. In mature rats (6 months), recognition of the novel object was improved following administration of BGC20-761. The difference in effects of BGC20-761 in young vs. mature rats may reflect the status of memory consolidation in these different age ranges 1.

Reference:
1.? Mitchell ES, Hoplight BJ, Lear SP, et al. BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology. 2006;50(4):412-420.