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  • N-(3-hydroxyphenyl)-Arachidonoyl amide
N-(3-hydroxyphenyl)-Arachidonoyl amide的可视化放大

N-(3-hydroxyphenyl)-Arachidonoyl amide

An irreversible COX-2 inhibitor

原价
¥650-8925
价格
520-7140
N-(3-hydroxyphenyl)-Arachidonoyl amide的二维码

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  • 货号: ajci14986
  • CAS: 183718-75-4
  • 别名: 3-HPAA
  • 分子式: C26H37NO2
  • 分子量: 395.6
  • 纯度: >98%
  • 溶解度: ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
  • 储存: Store at -20°C
  • 库存: 现货

Background

IC50: 2 μM


N-(3-hydroxyphenyl) -Arachidonoyl amide, also known as 3-HPAA, is an analog of AM404 (N-(4-hydroxyphenyl)-arachidonoyl amide), a selective inhibitor of carrier-mediated transport of arachidonoyl ethanolamide. 3-HPAA, metabolized by both cyclooxygenase (COX) -1 and COX-2, is an irreversible and selective inhibitor of COX-2 with an IC50 value of 2 M. 3-HPAA can be efficiently oxygenated to prostaglandin and hydroxyeicosatetraenoate products by prostaglandin endoperoxide synthase (PGHS) -2. It appears that 3-HPAA can be converted by PGHS-1 in a similar manner.


COX enzymes play elaborate roles in human physiology and pathology, involving neuronal, immune, renal, cardiovascular, gastrointestinal, and reproductive systems. COX enzymes are blocked by aspirin and a wide variety of other non-steroidal anti-inflammatory drugs, which makes them clinically important [1]. COX-2, overexpressed in cancer cells, promotes tumorigenesis and induces neo-angiogenesis. Additionally, it plays an important role in inflammation and pyrexia.


In vitro: Up to now, in vitro study of 3-HPAA is still in the development stage.


In vivo: Up to now, in vivo study of 3-HPAA is still in the development stage.

Reference:
[1].? Fitzpatrick, F. Cyclooxygenase Enzymes: Regulation and Function. Current Pharmaceutical Design. 2004; 10(6): 577-588.

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