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  • CH 223191
CH 223191的可视化放大

CH 223191

A potent antagonist of AhR

原价
¥762-2387
价格
610-1910
CH 223191的二维码

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  • 货号: ajci16682
  • CAS: 301326-22-7
  • 别名: 1-甲基-N-[2-METHYL-4-[2-(2-甲苯基)二氮烯基]苯基-1H-吡唑-5-甲酰胺
  • 分子式: C19H19N5O
  • 分子量: 333.39
  • 纯度: >98%
  • 溶解度: ≥ 33.3mg/mL in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR).CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM[1].


CH-223191 (0.1-10 μM; pre-treated 1 hour) inhibits TCDD-caused cytochrome P450 1A1 mRNA expression in a in dose-dependent manner[1].CH-223191 (0.1-10 μM; pre-treated 1 hour) causes a concentration-dependent inhibition of TCDD-induced cytochrome P450 enzyme activity[1].


CH-223191 (10 mg/kg; once a day; 25 days) suppresses cytochrome P450 1A1 expression and the intrahepatocyte fat content in liver, reduces activity of AST and ALT in TCDD-treated mice[1].


参考文献:
[1]. Zhao B, et al. CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. Toxicol Sci. 2010 Oct;117(2):393-403.
[2]. Kim SH, et al. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun;69(6):1871-8.

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