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- Akt/PKB (Protein kinase B)
- AKT Kinase Inhibitor
AKT Kinase Inhibitor
AKT Kinase Inhibitor 是一种具有抗肿瘤活性的 Akt 激酶抑制剂。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥3775.003020.00- +
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10mg￥6475.005180.00- +
- 货号: ajci16974
- CAS: 842148-40-7
- 别名: AKT激酶抑制剂
- 分子式: C16H19N7O3
- 分子量: 357.37
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].
The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1].
Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].
参考文献:
[1]. Saverio Alberti, et al. Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network. WO2013171777A2.
