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  • AKT Kinase Inhibitor
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AKT Kinase Inhibitor

AKT Kinase Inhibitor 是一种具有抗肿瘤活性的 Akt 激酶抑制剂。

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¥3775-6475
价格
3020-5180
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  • 货号: ajci16974
  • CAS: 842148-40-7
  • 别名: AKT激酶抑制剂
  • 分子式: C16H19N7O3
  • 分子量: 357.37
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].


The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1].


Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].


参考文献:
[1]. Saverio Alberti, et al. Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network. WO2013171777A2.

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