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  • Nimodipine
Nimodipine的可视化放大

Nimodipine

An L-type calcium channel inhibitor

原价
¥450-1300
价格
360-1040
Nimodipine的二维码

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  • 库存: 现货
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  • 货号: ajci17416
  • CAS: 66085-59-4
  • 别名: 尼莫地平; BAY-e 9736
  • 分子式: C21H26N2O7
  • 分子量: 418.45
  • 纯度: >98%
  • 溶解度: ≥ 108mg/mL in DMSO, ≥ 41.8mg/mL in EtOH
  • 储存: Store at -20°C,protect from light
  • 库存: 现货

Background

Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.Target: Calcium ChannelNimodipine is main use is in the prevention of cerebral vasospasm and resultant ischemia, a complication of subarachnoid hemorrhage (a form of cerebral bleed), specifically from ruptured intracranial berry aneurysms irrespective of the patient's post-ictus neurological condition. Its administration begins within 4 days of a subarachnoid hemorrhage and is continued for three weeks. If blood pressure drops by over 5%, dosage is adjusted. There is still controversy regarding the use of intravenous nimodipine on a routine basis [1, 2].


参考文献:
[1]. Janjua, N. and S.A. Mayer, Cerebral vasospasm after subarachnoid hemorrhage. Curr Opin Crit Care, 2003. 9(2): p. 113-9.
[2]. Allen, G.S., et al., Cerebral arterial spasm--a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med, 1983. 308(11): p. 619-24.

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