Edelfosine

Edelfosine ((R)-ET-18-OCH3) 是一种醚脂质类似物，具有抗 HIV 和抗肿瘤活性。

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库存: 现货

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5mg

￥3075.00

2460.00

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货号: ajci17616
CAS: 77286-66-9
别名: 1-O-十八烷基-2-O-甲基-SN-甘油-3-磷酸,2-O-methyl PAF C-18
分子式: C27H58NO6P
分子量: 523.73
纯度: >98%
溶解度: PBS pH 7.2: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

2-O-methyl-PAF C-18 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the sn-2 position. It has been shown to mediate a number of biological responses including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness in embryonic chick heart.[1] In rat astrocytes, 2-O-methyl PAF C-18 causes the release of large quantities of nitric oxide by a pathway involving activation of nitric oxide synthase.[2]

Reference:
[1]. van Blitterswijk, W.J., Hilkmann, H., and Storme, G.A. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 22, 820-823 (1987).
[2]. Cardile, V., Jiang, X., Renis, M., et al. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. Brain Research 715, 98-103 (1996).