骨化二醇一水合物（25-羟基维生素 D3 一水合物）是维生素 D3 的主要循环代谢物，是一种有效的 VDR 抑制剂。
Calcifediol is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) and is the best indicator of total vitamin D exposure [1].
The main circulating form of vitamin D, higher serum levels of calcifediol is associated with lower incidence rates of colon, breast, ovarian, renal, pancreatic, aggressive prostate and other cancers [2].
In bovine parathyroid cells, Calcifediol can reduce parathyroid hormone (PTH) secretion and mRNA synthesis [3]. In T-47D breast cancer cells, calcifediol mediated activation of VDR (the vitamin D receptor), which was associated with endocytosis of DBP (vitamin D binding protein). So T-47D breast cancer cells can rapidly internalize DBP [4].
In the pooled study included 616 colorectal adenoma cases and 770 controls, the association between circulating 25(OH)D3 and colorectal adenoma risk was estimated through multivariable logistic regression. The higher circulating 25(OH)D3 concentrations were significantly associated with lower colorectal adenoma risk [1].
参考文献:
[1]. Fedirko V, Bostick RM, Goodman M, et al. Blood 25-hydroxyvitamin D3 concentrations and incident sporadic colorectal adenoma risk: a pooled case-control study. Am J Epidemiol, 2010, 172(5): 489-500.
[2]. Garland CF, Gorham ED, Mohr SB, et al. Vitamin D for cancer prevention: global perspective. Ann Epidemiol, 2009, 19(7): 468-483.
[3]. Ritter CS, Armbrecht HJ, Slatopolsky E, et al. 25-Hydroxyvitamin D(3) suppresses PTH synthesis and secretion by bovine parathyroid cells. Kidney Int, 2006, 70(4): 654-659.
[4]. Rowling MJ, Kemmis CM, Taffany DA, et al. Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells. J Nutr, 2006, 36(11): 2754-2759.
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