A degradation product of teicoplanins
Teicoplanin A3-1, also known as Antibiotic L 17054, is a glycopeptide antibiotic derived from Actinoplanes teichomyceticus and produces a potent broad spectrum antibiotic activity against gram-positive bacteria.
Teicoplanin A3-1 is a common degradation product of teicoplanins A2-1 to 5, which results from cleavage of the lipoaminoglycoside substituents. Teicoplanins are glycopeptide antibiotics produced by A. teichomyceticus which are effective against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and E. faecalis. As an antibiotic complex, teicoplanin consists of five closely related factors, T-A2-1, 2, 3, 4 and 5 and a more polar factor, T-A3-1. Additionally, as a glycopeptide antibiotic belonging to the same family as vancomycin, teicoplanin blocks cell wall synthesis in Bacillus subtilis, which is accompanied by an intracellular accumulation of UDP-N-acetylmuramyl-pentapetide [1]. Due to the greater antibacterial activity of teicoplanin than other agents, it has been thoroughly studied as a β-1actamase-resistant agent for the treatment of human infections caused by streptococci and staphylococci, including enterococci [2].
In vitro: Up to now, in vitro study of Teicoplanin A3-1 is still in the development stage.
In vivo: Up to now, in vivo study of Teicoplanin A3-1 is still in the development stage.
参考文献:
[1].? Somma, S., Gastaldo, L., & Corti, A. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. Antimicrobial Agents and Chemotherapy. 1984; 26(6): 917-923.
[2].? Traina, G., & Bonati, M. Pharmacokinetics of teicoplanin in man after intravenous administration. Journal of Pharmacokinetics and Biopharmaceutics. 1984;12(2): 119-128.
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