DL-AP5

A competitive NMDA antagonist

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库存: 现货

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5mg

￥762.00

610.00

- +
10mg

￥1200.00

960.00

- +
25mg

￥2812.00

2250.00

- +
50mg

￥5162.00

4130.00

- +

已选 0 种 0 瓶

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货号: ajci18654
CAS: 76326-31-3
别名: DL-2-氨基-5-膦酰基缬草酸,DL-2-Amino-5-Phosphonovaleric acid，2-APV
分子式: C5H12NO5P
分子量: 197.13
纯度: >98%
溶解度: 10mg/mL in PBS, pH 7.2
储存: Store at -20°C
库存: 现货

Background

DL-AP5 is the racemic version of the selective N-methyl-D-aspartate (NMDA) receptor antagonist, D-AP5.[1] Whereas D-AP5 is the active (?)-stereoisomer that competitively inhibits the glutamate binding site of NMDA receptors (Kd = 1.4 μM), the (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.[1] AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.[2]

Reference:
[1]. Evans, R.H., Francis, A.A., Jones, A.W., et al. The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br. J. Pharmacol. 75(1), 65-75 (1982).
[2]. Morris, R.J. Synaptic plasticity and learning: Selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J. Neurosci. 9(9), 3040-3057 (1989).