Thiolutin

An inhibitor of Hsp27 and RNA polymerases

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1mg

￥1287.00

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￥3837.00

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10mg

￥7025.00

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货号: ajci18724
CAS: 87-11-6
别名: 硫藤黄素,Acetopyrrothin
分子式: C8H8N2O2S2
分子量: 228.28
纯度: >98%
溶解度: DMF: 0.5 mg/ml,DMSO: 1 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
储存: Desiccate at -20°C
库存: 现货

Background

Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36[1]. Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation[2].

参考文献:
[1]. Lauinger L, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol. 2017 Jul;13(7):709-714.
[2]. Jia Y, et al. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell Stress Chaperones. 2010 Mar;15(2):165-81.